Some depressed patients have improved mood after the use of another drug that inhibits monoamine oxidase enzyme activity, preventing monoamines from deteriorating - in fact, as a side effect.
Based on these clinical observations, the first group of modern antidepressants, namely
monoamine oxidase inhibitors, were developed. However, nothing is known about which monoamines were associated with depression at the time.
In the 1960s, JJ Schildkraut from Harvard University formulated the catecholamine hypothesis for mood disorders.He assumed that the main cause of depression was norepinephrine deficiency in some brain-regulating circuits, while vice versa.
But in the 1990s, research focused on serotonin. The main reason was the success of Prozac (fluoxetine) and other SSRIs (selective serotonin reuptake inhibitors).
My personal story starts right here.
Sertralin....
Labels: Chemical Solutions for the Black Dog
