Your Miraculous Secretion in Your Brain
In recent years, we have heard of an interesting disease that has been seen all over the world: anorexia nervosa. This disease occurs in people who hate obesity. The person first tries to lose weight by dieting, but as a result of excessive diet therapy, it reaches an irreversible point. In this case, the slimming cannot be stopped and the person can no longer eat or eat, or vomit, removing all the food back.
Orexin is a substance of nature (neuropeptide) that was discovered in 1998 and secreted in the brain. This protein is responsible for adjusting conditions such as wakefulness, appetite and arousal. In the side hypothalamus of the human brain, there are tens of thousands of neurons that secrete orex. Orexins were discovered as appetite-boosting substances, but later on, alertness, regulating the body's energy use and additional functions of the internal organs were also identified.
Orexins perform very important tasks for the development and maturation of brown adipose tissue, which is more effective in infants. Fats in brown adipose tissue are converted to heat directly without ATP production. In this way, body temperature is increased. This task of brown adipose tissue is to protect the body against diseases in cold weather. In mouse experiments, it was found that the body temperature dropped and the mice were not able to consume fat in animals without anorex in their bodies. Therefore, it is possible to say that orexins are tasked with accelerating energy expenditure, increasing body temperature, protecting the body against diseases associated with cold and preventing obesity.
Orexins are responsible for adjusting metabolic events and speed in the body. It is also responsible for the regulation of the circadian rhythm, which is a daily sleep-wake cycle. These tasks are not to cause sleep, but to increase alertness. The orexins cause increased secretions of dopamine, norepinephrine, histamine and acetyl choline, which are hormones involved in the proper functioning of the sleep-wake cycle in the brain. All of these hormones are substances that increase alertness.
With the destruction of neurons responsible for producing orexins, a very important disease occurs. This disease is called "narcolepsy". Narcolepsy is actually a serious sleep disorder. The patient suffers from sudden, inconsistent and excessive sleepiness during the day, irregular night sleep, sleep paralysis, various hallucinations, and a temporary muscle paralysis called cataplexy. Such a patient suddenly falls into REM sleep while talking, driving and watching television. Muscle paralysis, which comes with REM sleep, piles the person where it is as if he fainted. Sometimes it remains immobile for a while, even if it wakes up. This ailment, which usually starts in the twenties, can be caused by organic causes such as brain inflammation or urs, or from hidden hostile impulses.
Narcolepsy is a disease that disconnects a person from life, makes him unable to fulfill his daily routines and has no cure for now. Only treatments that facilitate the lives of patients can be applied. One of its most obvious symptoms is the excessive tendency to sleep during the day, even if you get enough sleep at night. People with narcolepsy pile up and fall asleep at their most unexpected places and times, often without being noticed by themselves. Sleep attacks during the day are seen as the need for sleep becomes unbearable, sometimes by noticing and sometimes not arriving. So much so that narcoleptic people need to take precautions for themselves while doing their daily work, because frequent uncontrolled drops cause injuries.
Cataplexy is a condition in which the muscles lose their function, speech becomes incomprehensible, and the body in the form of a seizure that collapses the body as a result of the weakness of the neck or knees. This seizure can occur with emotional reactions such as excessive laughter, anger or fear. The duration of the cataplexy can be extended from a few seconds to several minutes. One does not lose consciousness throughout the seizure, only body functions are paralyzed. So much so that most of the time, those who have had this attack in public places, seem to be drunk, drug-takers. They can hear and see, but they cannot answer.
Sleep paralysis is the condition of not being able to speak or move temporarily while awakening. Although this is a frightening situation, it is not dangerous. Hypnogogical hallucinations, on the other hand, are dreamy and dreamy, seen during sleep diving and awakening. Although daytime sleepiness, sleep paralysis, hypnogogic hallucinations, and disorders that can be observed especially in people who have not slept sufficiently, cataplexy is a condition specific to narcoleptic patients only.
Orexins are responsible for increasing the amount of nutrition. These duties are not about meeting the daily food need of the person. Orexin has an effect on increasing appetite even if the person does not need nutrition. For this, it suppresses the satiety center and allows the person to continue eating despite being satiated.
