The key to puberty in the molecule kisspeptin
Adolescent age is gradually decreasing, and the reason for this is not yet known. Families are worried. Beginning of physical development and sexual impulses far before mental maturation worries societies. The genetic button that fires puberty is finally found.
A molecule called "kisspeptin" (kisspeptin) that stimulates and activates reproductive hormones from hibernation during childhood. When it is taken under control, the onset of puberty can be delayed. Or, by increasing the rate of kisspeptin, sexual motives can be activated.
The process that has become the nightmare of all of us in transition from childhood to youth: Adolescence. And another nightmare is that the adolescent age is brought forward. It is never known when to start. It can start at the age of 8 in girls or 13-14. Even if boys start a few years after girls, theirs are in a wide range of time. Moreover, they are all in my tongue, which is defined as "normal". Hormones start to work, affecting the whole body. Everything is under the control of hormones, from how long the neck will grow, whether the bones will be strong, the risk of getting breast or prostate cancer after 20-30 years, or even your mental health.
It was not known what had sparked puberty until recent years. It was not clear why some children started so early and others late. The prevalent blood was that puberty started in the brain first. Bodily signs followed. The hypothalamus in the brain was suddenly beginning to secrete the gonadotropin hormone known as GnRH, which leads the chemical process of puberty. The question that could not be answered was: What is the element that triggers GnRH secretion?
The answer finally came after many years of research. The world of science has announced that there is a genetic button that fires adolescence.
It is a molecule called "kisspeptin" (kisspeptin) that activates the reproductive hormones that hibernate during childhood.
This molecule can be taken under control and the onset of puberty can be delayed. Or vice versa, by increasing the rate of kisspept, sexual motives can be activated. Both are of great importance for the scientific world.
The present invention is expected to make a major contribution to the treatment of irregular puberty.
In experiments on mice, it was found that reproductive hormones act when kisspeptin is given to young animals. According to research published in the New England medical journal, the gene called GPR54 controls a protein related to hormone secretion during puberty.
SAUDI DISCOVERED IN THE FAMILY
The research was initiated upon the application of a Saudi Arabian family who had problems in transitioning to Massachusetts Hospital in the USA. Experts looking at the blood samples taken from each of the family members found that this gene mutated in the samples they received from family members who could not go into puberty, and the gene was normal in other individuals.
On the other hand, British biotechnology firm Paradigm Therapeutics contacted American doctors and reported that they deleted the GPR54 gene in a guinea pig.
American and British experts believe that the protein that this gene controls helps secretion hormones that promote physical development during puberty. The world of science now believes that by doing the same practice on humans, children who are unable to undergo adolescence normally can be treated.
ONE OF 10 THOUSAND CHILDREN IS PROBLEM
Another problem that is increasingly serious in communities is the early adolescence of many children. According to the news in the journal New Scientist, the period of puberty has been getting earlier in the last 250 years. In 18th century Europe, girls saw menstruation for the first time at the age of 17, and a hundred years later, menstrual age decreased to 14. Today, the average age of first menstruation is 13.
"The adolescence limit is rapidly going down," says the researchers. There is no concrete data on the cause yet. However, there are different opinions. For example, one of the heads of the team that made the invention, Dr. "Now we have evidence that the key points that start puberty are the GPR54 gene and the kisspeptin protein molecule that fires it," says Tony Plant. "Early puberty is a very important field of research. Maybe new hormones maybe nutrition is effective," says Professor Ilpo Huhtaniemi at Imperial College London.
The world of science is working to develop a pill that controls puberty.
THE MOTHER-DAUGHTER BEGINS AT THE SAME AGE
From a molecular biological perspective, the adolescent puzzle seemed to be solved by the discovery of the GPR54 gene, which produces the KiSS-1 protein and a nerve cell receptor.
A complex signal chain initiates the adolescence process. GnRH (gonadotropin releasing hormone / gonadotropin-releasing hormone) triggers pituitary stimulant secretion. This substance, on the other hand, stimulates rats and ovaries to produce sexual hormones.
Unfortunately, this information is not enough to explain the beginning of puberty. How the Kisspeptin molecule is exposed is still a mystery. Y
