Help For Mood Disorders: 04.20

UFO AND HUMAN PSYCH.

PHYSIOLOGICAL AND PSYCHOLOGICAL TRACES OF HUMAN COMPETITION ON THE HUMAN (DEDICATED TO THE UFO ADMISSION OF PENTAGON)

The issue of how the world people are affected in encounters with UFOs (close encounters, especially close types 2 and 3) attracted the attention of some researchers. This influence has extended beyond the psychology of the human and has extended towards the psychic side. The literature on the subject is full of examples of this situation; You will find some of them in my review below but first, let's start with a news story that we have been living in recently and that was effective in writing this article and shocked us all.

UFO images verified by PENTAGON and NASA

The Pentagon and NASA confirmed the UFO images taken in 2004-2015. They did this by sharing the following images on social media. Frankly, the whole world now seems to have believed in the reality of this situation. Take a look at the video and see what you will think ..

The Navy previously accepted the accuracy of the videos in September of last year. According to Pentagon spokesperson Sue Gough, they officially decided to publish it now to "eliminate misunderstandings about whether public images are real or if there is more in the videos."
“As I got close to it … it rapidly accelerated to the south, and disappeared in less than two seconds,” said retired US Navy pilot David Fravor. “This was extremely abrupt, like a ping pong ball, bouncing off a wall. It would hit and go the other way.”(...)

Now let's list the most common and common reactions of human physiology and psychology to close encounters with UFOs. , increase / decrease in intelligence level, psychosis. In addition, the following reactions were found, mainly related to the spiritual side of the observer:

1-Telepathic communication and cleansing detection (clairvoyance)

2-hunch or prophecy

3-Materialization, materialization

4-Suddenly the ones coming with UFOs appear and become invisible

5-Telekinesis (moving items, voices and clicks of unknown cause, radio, tv, tlf. And other electrical devices affecting functions

Spiritual / thought photos of UFOs

7-Audio tapes about UFOs

8-Teleportations of observers or belongings

9-levitation

10-Uncanny and poltirgayst events.

As you can see; There is a connection between extraterrestrial vitality or the intelligent life issue in the universe and parapsychology (even metepsychic) and we want to convey you in such an approach.
Despite this connection, this is the least studied aspect of UFO events or people who have experience with UFOs so far; In other words, the psychological, parapsychological, even parapsic / metapsic side of the work (compared to the astronomical and physical side)…
However, a small amount of research so far revealed a common feature of those who met with intelligent beings coming with UFOs, which is; these are the tendencies of people to ethno. Yes, these people are very sensitive to spiritual stimulation.
I will may give some examples of the psychological and spiritual responses of the world human to the UFO phenomenon in this article and some in my other articles. The ufos' temporary / permanent effects on humans, animals and the environment:
In some of the close encounters of the second type, some of the witnesses who observed the incident; There is shock, depression, unexplained fear and uneasiness, and in some of them (especially in close encounters of type 3), the situation of feeling unexplained mental suggestions as his fear is meaningless has been experienced. Emerging at this time; An experience involving incidents such as shock, loss of consciousness, sudden hot flashes, radiation or electromagnetic effect, and the incidents that were taken, occurred in an event that took place in Brazil.

The protagonist of the incident, Antonio Bogado La Rubia, left his house at 2:15 am to go to his mission by shuttle. The road to the stop of the shuttle bus passed through a deserted area. Because Antonio's house was already in a relatively desolate area outside the city, and there were no dwellings other than a few small huts in the immediate vicinity of his house. In order not to miss the service vehicle, trying to move towards the stop with quick steps; A little further (in his own words), when he suddenly saw "something like a hat", he was naturally startled and as if he were frozen. As soon as he stopped, he was caught on both sides (again in his words) by the "two men".
Antonio soon found himself in a place he called "that thing ...". It seemed as if he was standing there. Here, there were about 10-12 "men" on both sides, almost as big as his own. Antonio did not hear any sound except for the breathing and the breathing of these “men”. Panicked, Antonio wanted to shout, but he was amazed to see that his voice was not sounding. After this first split, Antonio; It was placed in the side chamber dominated by blue and white lights. Here, a blood sample was taken from the middle finger of his right hand. Meanwhile, he was watching his own image on the screen (but his images, including the near future).
For a while he gathered all his strength and screamed at one, and said: "Who are you, what do you want from me?" Probably the "men" beside him were not expecting such a reaction from Antonio, all of them leaping back a few steps in a hurry. But almost immediately at the same time, the sound of our hero was cut off with a beam of light pointed at Antonio. Aside from making his voice, he could not even move his hand and arm. Antonio later tried to describe this situation as follows: “I thought for a moment that the men intend to fry me alive. As if I was on fire. I fried like a pomegranate under that light. When they pulled the light off me, I was relieved a little. ”Antonio doesn't know how long he stayed in that strange place; before finding out how he was, he found himself in an abandoned hut near where he was first taken / taken. When he recovered, he looked at his watch, pointing at 3:55. So, it was 40 minutes in the "thing".

When he came to work with difficulty, he still felt like a fire. So much that he asked his friends to squeeze water on him with a hose. But it did not help, and they took him to the worker's health center: his body temperature was 42 degrees. While at the health center, Antonio was examined by doctors in a half-naked state, he remembered his own image on the screen while he was in "that thing". Yes, at this moment he was shown to him in "that thing", and hours ago ...
In the hours after this medical examination, the emotional symptoms / reactions of the person were just like that of a child; There were even times when she cried like a baby. His fire showed ups and downs from time to time. Vomiting and diarrhea continued along with mild swelling in some parts of the body.
He had occasionally fried some parts of his body from scratching. He wanted neither to be touched nor to wear anything. It was almost as if it was burning in his mouth, where he felt constantly dry.
Antonio also had psychological tests, but it turned out to be normal. On the other hand, UFO researchers, of course, were also interested in the subject and Antonio. One of them, local researcher Irene Granchi, reminded a third-party close-up event similar to what happened to Antonio in Villegas in Mendoza Peccinetti in 1968: There were cases of taking a blood sample from the middle finger and watching TV.

VASOPRESSIN AND OXYTOCIN

VASOPRESSIN

A neurotransmitter produced by the hypothalamus. After entering the bloodstream, it turns on pumps that absorb water in the kidneys and keep them away from the bladder. Hypothalamus damage also damages vasopressin that is exactly what happened to Mr. O...
He shot himself with a gun from his right temple. When he was found twelve hours later and taken to the hospital, it was understood that the lead damaged the optic nerves and the man was blind. The relevance of the event to vasopressin begins right here. A total of 396 g in the first two days of recovery period. urinated. In the following days, he pissed 4.5 liters a day, which corresponds to three times the daily amount of urine of an average man.Even up to 5.5 liters of urine in the following days. The reason for this was that the bullet swelled the brain tissue in the path followed by crushing the hypothalamus. When the hypothalamus stopped the production of vasopressin, the urinary bladder, which filled up rapidly, passed to the discharge without stopping.
These are all from Sam Kean's mystery of the human brain.

Also known as antidiuretic hormone or ADH, the vasopressin hormone is released from the magnocellular nuclei of the hypothalamus. From here it passes to the neurohypophysis and from there it enters the bloodstream. It helps regulate the amount of water in the body by controlling the amount of water that the kidneys remove from the body.
The hormone vasopressin is an oligopeptide consisting of 9 amino acids. The amino acids that make up this hormone; cysteine, tyrosine, glutamine, proline, an amino group, phenylalanine, arginine, asparagine and a carboxyl group.
Although the main function of the vasopressin hormone is to regulate processes in the kidneys, this hormone is also effective on the cardiovascular system and the central nervous system.
This hormone is released in response to hypertonicity in body fluids. This allows the kidneys to reabsorb water and return it to the blood from the nephron tubules, returning the tonicity of body fluids to normal.
As a result of the reabsorption of water in the kidneys, urine becomes more concentrated, and therefore the amount of urine is reduced. That is, blood pressure may drop because it causes a slight vasoconstriction when there is a dense release of vasopressin.

Effects of Vasopressin Hormone on the Central Nervous System
Antidiuretic hormones released from hypothalamic neurons regulate blood pressure and body temperature. It has also been proven that this hormone may have pain relieving effects depending on gender and stress.

OXYTOCIN (A VERY BEAUTIFUL HORMONE)

Oxytocin, also referred to as a love hormone, is a hormone that not only makes people fall in love, but also allows the mother to connect her child with special love. According to scientists, the oxytocin hormone secreted when falling in love is also secreted during orgasm and childbirth. Stating that the oxytocin hormone works like a switch and, once released, opens new ways of communication between cells, arguing that people with low oxytocin-sensitive receptors have difficulty in long-term relationships.
There are some symptoms that will allow you to understand that oxytocin has entered your body; The creeks start to flow, gushing, the rabbits jump, the legs stretch into the water, and the clouds begin to look like whipped cream whipped foams. Stops stomach feeling hungry. If oxytocin is secreted, you will not feel hungry and thirsty; It is true. However, you should drink water, quaff.
You have to go and eat until it gets clogged so that the amount of oxytocin in your body increases, until it reaches an uncertain amount. Small movements will increase the amount of oxytocin in your body and accelerate their activation. Thanks to oxytocin, you say hello to a harmonic and simultaneous world.

Plasma oxytocin level was found low in patients with major depression. In women with unipolar or bipolar depression
It has been reported that oxytocin levels are lower than healthy controls and normal in men. In animal models, oxytocin has been shown to show antidepressant activity. In addition, it has been observed that oxytocin infusion increases serotonin release in the refined nucleus, the basis of which selective serotonin reuptake inhibitors (SSRI) act.
Serum oxytocin level was found to be significantly higher in patients with bipolar disorder than healthy controls. In addition, patients with manic episodes have been reported to have significantly higher oxytocin levels than patients with depressive episodes or remission.
It has also been reported that giving oxytocin to the mother to induce labor increases the risk of developing bipolar disorder in the baby 2.4 times in the future (Freedman 2015). The number of studies investigating the role of oxytocin in the etiology of bipolar disorder is limited, as far as we know, there are no studies investigating the effectiveness of treatment.

ACTH, POMC AND THE MSH

ADRENOCORTICOTROPIC HORMONE (ACTH)

Hormone that secreted by the pituitarial gland in which located the lower part of the brain, affecting the adrenal glands and causing cortisol secretion.

Secretion properties of ACTH

Circadian rhythm:
Plasma ACTH and cortisol level;
- It starts rising at 03:00, peaks at 08,
- Minimizes to midnight
Circadian rhythm time, regarding the sun;
- Light and dark shifts synchronize with the circadian rhythm of sleep / wakefulness or social activity.
Circadian rhythm is normal in AY, disordered in CS.
Pulsatile secretion:
Episodic release with short and large amplitudes.
Pulsatile is released every 39 minutes,
- The half-life of an swing lasts 19 minutes.

PROOPIOMELANOCORTIN (POMC)

POMC neurons are important regulators of blood sugar and energy balance. Proopiomelanocortin (POMC) is converted to alpha-melanocyte-stimulating hormone (alpha-MSH), which acts centrally on the melanocortin receptor (MC4) to reduce nutrient intake. A new study from the UT Southwestern Medical Center shows that POMC neurons that positively affect metabolism in mice remain active for up to two days after exercise.

Melanocortin circuit
The melanocortin circuit in the brain is one of the ways the body regulates food intake through stimulation and inhibition. This circuit is found in both humans and mice. Neurons that release melanocortins (peptide hormones) are located in the nucleus arcuate of the hypothalamus.
First of all, melanocortins include POMC (pro-opiomelanocortins). When these neurons secrete alpha-MSH, they cause decreased appetite, lower blood sugar levels, and increased energy. When these neurons release AgRP, it actually increases appetite and reduces metabolism. Previous studies have already shown that dieting or starving can positively affect this system. However, the system has never been associated with movement before.

Short and long term effects
In this study, the effects of exercise on POMC and NPY / AgRP were measured with training mice. An exercise with three 20-minute treadmills resulted in short-term loss of appetite for up to six hours. "This result can explain why people at a nervous level don't immediately feel hungry after a workout," a researcher said. Said
The long-term effects of training have been seen in POMC neurons that are known to improve glucose metabolism. In addition, these neurons remained active longer if they expressed the leptin receptor. Leptin is our satiety hormone that regulates the melanocortin circuit together with our hunger hormone ghrelin.

Benefits for glucose metabolism
A researcher doesn't even do a lot of exercise to change the activity of these neurons. for glucose metabolism. "He also concluded that a better understanding of neural connectivity by movement can help patients with type 2 diabetes, for example.

Other POMC functions
POMC (pro-opiomelanocortin) is the precursor of several neuropeptides and hormones, such as beta endorphins, melanin and cortisol. Beta endorphins, among other things, reduce the release of glutamate and substance P, which gives a strong analgesic effect. Cortisol is released by ADOM in the adrenal gland via POMC. Cortisol is our 'activity hormone' and is important for the release of glucose into our body. In short, together with melatonin, it determines our rhythm of sleep-wake and plays an important role in our immune system and response to stress. Cortisol is also an important hormone to act and offers the above-mentioned benefits for blood sugar and energy balance.

MELANOCYTE STIMULATING HORMONE

To date, the melanocyte stimulating hormone has always been pushed into the background. It fell into contempt, was said to be trivial; We were said to know that it is only secreted from the pituitary and only has a peptide structure. There were even those who shot below the waist saying that it was no other crap except that it was acth's byproduct.
Its effects on pigmentation, appetite, sexual arousal, and bone regeneration were previously known. The researchers said, "If it is effective in bone, can it benefit a tooth?" Based on the question, they tried to develop the synthetic gel and rub it into already rotten teeth (in mice, of course) and the result: voila! "Caries disappeared" in a short time like 1 month. This new gel does not prevent caries. Keep brushing, of course, but it is not a scientific breakthrough to heal the caries.
It officially means goodbye to filling and canal treatment, which results in a great deal of history of dentist fear. I was already guessing, let's say that such a thing will happen, or it should happen. Carving those teeth or something ... sounds like an awesome primitive event. But it has been the year 2020, I ask you to lift it.
..............................
It is effective in the formation of skin color, but it is interesting that in humans the receptor of this hormone has not been shown.
Most of our information is from mice. Many things found in mice are not adaptable to the human body. Many experiments are made by means of mice since it is almost impossible to experiment on human beings. Unfortunately, mice that are distantly related are not like human beings.
.............................
Prolyl-leucyl-glycinamide (MRIH-I), that is the melanocyte-stimulating hormone (MSH)-release inhibiting hormone is a hypothalamic hormone active in animal systems used as models of depression.In a double-blind, clinical trial, four of five patients with mental depression, who received 60 mg of MRIH-I for each of six consecutive days, experienced marked improvement for their symptoms within. two to three days.
The preliminary nature of these findings, however, is emphasized by the improvement in two of four patients receiving a placebo and only two of five patients receiving 150 mg of MRIH-I.
Rudolph H. Ehrensing, MD; Abba J. Kastin, MD
Author Affiliations
Arch Gen Psychiatry. 1974;30(1):63-65. doi:10.1001/archpsyc.1974.01760070047007

GALANIN-GASTRIN AND CHOLECYSTOKININ

GALANIN

Galanin prevents the emergence of other chemicals in the brain, so drugs that stop this substance increase the release of other chemicals that correct depression in the brain.(HT-2157-GALR3 antagonist). Galanin is a neuropeptide encoded by the GAL gene, located in the brain, spinal cord and digestive system. Galanin's intracellular signaling mechanism is via G-protein coupled receptors.
The functional role of galanin is largely unknown, but it gets involved in regulating and blocking the action potential of neurons. It also has a role in many events such as perception of pain, eating behaviors, sleep and wake cycles, cognitive functions and mood regulation in humans. Galanin neurons in the preoptic area of the hypothalamus can also control parental behavior. This neuropeptide is associated with many diseases, such as Alzheimer's disease, epilepsy, depression, and eating disorders. It has been proven by scientific studies that galanin neurons, which is a very unheard of neuropeptide, have a protective effect and can even trigger new neuron formation (neurogenesis).

Galanin as a modulator of anxiety and depression and a therapeutic target for affective disease

GASTRIN

It is secreted from G cells in the antral region in the stomach. G cells and other enteroendocrine cells also contain noradrenaline and serotonin-related amines, which are also called APUD cells. Other cells that produce gastrin are TG cells found throughout the stomach and small intestine.
It is also found in the anterior and posterior lobes of the pituitary, hypothalamus, m oblongata, vagus and sciatic nerves.

EFFECTS OF GASTRINE
The main effect is the secretion of stomach acid and pepsin
Stimulating the growth of the small and large intestinal mucosa (trophic effect)
Stimulation of stomach motility
Stimulating ileum motility and mass movement in the large intestine
Stimulates insulin secretion after a protein-rich meal

FACTORS EFFECTING GASTRINE SECRETION
Stimulation of vagus, calcium, adrenaline, protein breakdown products in the stomach; in particular, the presence of amino acids increases gastrin secretion.

The relationship of depression to metabolism

We know that most of the gastrointestinal hormones affect the brain and regulate the hunger-satiety mechanism. However, these hormones can determine our mood by doing more than that. For example, leptin is closely related to hippocampal plasticity. In addition, leptin has been observed to reduce dopamine release in the ventral striatum of rats. Activation of leptin receptors also inhibits dopamine release by preventing the firing of dopamine neurons here in the ventral tegmental area.

In addition to the recent diagnosis of diabetes, the probability of depressive behavior is between 12.8% and 29% in men, while it is between 23.8% and 30.5% in women. These rates are evidence of a close relationship between diabetes and depression.

Depression is also thought to be caused by the irregularity of the feedback of the ghrel in regions of the brain that regulate mood. Ghrelin has antidepressant effects in mice and humans. It acts as a dopaminergic and regulates the reward system. Carbohydrates, on the other hand, are the most effective nutrients that suppress ghrelin release. The interesting thing is that Ghrelin increases in the body in situations such as chronic stress and recurrent social defeat, and subsequently helps to cope with stress by creating an antidepressant effect on the body.

Another molecule that we think has to do with depression is Insulin-Like Growth Factor (IGF). IGF increases hippocampal neurogenesis and central sensitivity of the insulin signal in this way reduces depressive symptoms.

Blockade of cholecystokinin receptors in mice reversed depressive behavior. Chronic antidepressant treatments also reduced the release of cholecystokinin.

Genetic and pharmacological studies on rodents have shown that GRP (Gastrin Releasing Peptide) improves synaptic plasticity and anxious, depressive behavior aspects in areas of the brain, such as the hippocampus and amygdala. Behaviors, including food intake, social behaviors, learning, memory, and mood, are modulated by GRP in rodents.

Folate products, omega 3 fatty acids, monounsaturated fatty acids, olive oil, fruits and vegetables are also very important for the mood. Insufficient intake of these nutrients for certain reasons can trigger the risk of depression.

CGRP-CRH-UROCORTIN

CALCITONIN GENE RELATED PEPTIDE

CRGP (calcitonin gene related peptide) is a molecule that appears to have played an important role in migraine formation since the 1980s. It is involved in the communication between nerve cells and provides the expansion of the vessels (vasodilation) especially in areas where the need for blood increases in the brain. However, this vasodilating feature of CGRP can trigger a headache by causing the body to give an abnormal reaction in migraine patients. In the studies conducted after the learning of this information, the levels of CGRP in the body were measured in migraine patients and healthy individuals without migraine, and this molecule was found to be excessive in the body of migraine patients.
Moreover, headache could indeed be triggered in migraine patients who were given CGRP externally in clinical trials. The culprit was identified and it was time to catch him. Cornering CGRP The first way scientists tried was the simplest. CGRP, which causes migraine, was said, "Let's send a molecule that prevents CGRP from working and prevents it from working, and migraines will end". Although it seems logical and has been shown to be beneficial in many migraine patients, this method was abandoned because important side effects were observed in some patients.
CGRP is an important molecule for the brain to function normally, and it's not something we want to completely neutralize it in the body. Plan B has been launched: disabling CGRP is dangerous, so let's shut down the receptors it needs to act in the brain, and prevent CGRP from triggering its headache, although it can continue to work normally! This idea was put into practice and it was seen that it worked better than the first method and was successful in treatment with less side effects.

CORTICOTROPIN-RELEASING HORMONE

Researchers, who have been trying to overcome stress for years, have made an important step by exploring the center of stress in the brain. According to the information announced at the medical congress held in Bristol earlier this month, the starting point of the stress reaction is located in the '' hypothalamus '', which is a walnut-sized area inside the brain. The nerve cells in this region release the hormone ‘corticotropin '(Crh) in an undesirable situation. This hormone also causes the secretion of another hormone called 'adrenocorticotrope' (ACHT). This hormone flows into the adrenal glands, mixed with blood. The adrenal glands start producing hormones of adrenaline and cortisol, and fat cells begin to spray sugar. The heart rate is accelerating, blood pressure rises to provide energy transfer to the muscles. In such cases, one cannot find opportunities for sex or digestion. However, after the danger passes, the body brakes, cortisol produced with adrenaline returns to its center in the brain. The alarm condition is ending.

The problem starts when the energy that emerges in the stress seizure cannot find an outlet that can act as a valve. Nerve cells can be damaged and dangers such as heart attacks and epileptic seizures may occur. Scientists now state that, thanks to these findings, stress can be overcome more comfortably with hormonal-stabilizing treatments.

Chain reaction in the body

During an stressful event, the hypothalamus releases the CRH hormone. CRH stimulates the pituitary gland to form the hormone ACTH. This reaches the adrenal glands through the bloodstream. The produced adrenaline and cortisol also activate the subcutaneous glands (thymus), defense cells in the spleen and bone marrow. Then cortisol brakes the reaction at the starting point.

UROCORTIN

The most important factor that enables an individual to meet a stranger is the fear reaction that occurs in the brain as a result of the mystery and uncertainty before meeting. Urocortin and similar chemicals formed during fear put the brain circuits under stress. In order to eliminate this tension and stress, we meet the person in front of us. Urocortin is also anorexigenic agent.

NEUROMEDIN B- BRADYKININ-CALCITONIN

NEUROMEDIN B (NMB)

In mammals, neuromedin B (NMB) is a member of the bombesin-like peptide family, which has been shown to reduce food intake when administered systemically.

BRADYKININ

Bradykinin;

- is a vasodilator

- causes contraction of smooth muscles

- increases the permeability of the vessels

- is pain forming

- is blood pressure lowering

- is the cause of the hacking dry cough

CALCITONIN

Calcitonin pathway

Calcitonin is a hormone secreted by the thyroid gland and produced by body cells. Calcitonin reduces the concentration of blood calcium levels when it rises above the normal level. In fact, it is exactly effective on the bones. Its main task is to lower the level of calcium in the blood. Calcitonin has many domains, such as slowing bone resorption.

What are the duties of calcitonin?

It opposes the effects of parathyroid hormone (PTH), which helps to increase blood calcium levels.
It lowers blood calcium levels by suppressing osteoclast activity in the bones and increasing the amount of calcium excreted in the urine.
In addition to increasing the calcium absorbed by the kidney, it also prevents the absorption of calcium from the intestine.
It provides the normal level of salt, calcium and phosphorus in the blood.
It helps the bones to become harder and harder.
It prevents bone loss.
It ensures that hormones such as T3, T4 work properly.

Causes of high calcitonin;

- Some types of lung cancer
- Pregnancy
- Chronic renal failure
- Impaired bone marrow diseases such as myeloproliferative diseases
- The onset of pancreatic tumor
- Tumor that starts somewhere between the stomach and intestine and usually occurs in the digestive tract
- Tumor known as Zollinger ellison syndrome, located in the pancreas and duodenum
- Various thyroid diseases
- Small or large cell lung cancer
- Breast and prostate cancer
- Mastocytosis tumors, which means that the mast cells grow suddenly and appear in one or more organs
- Tumors occurring in the gastrointestinal tract, consisting of the mouth, esophagus, stomach and intestines
- Medullary thyroid, a type of tumor originating from parafollicular C cells
- Failure to build enough red blood cells caused by B12 deficiency (pernicious anemia)
- In cirrhosis caused by alcohol
- Inflammation of the pancreas
- Inflammation of the thyroid gland
- Pseudohypoparathyroidism disorder with symptoms such as short stature, brachial motility, obesity, mental retardation, round face appearance, subcutaneous calcification
- Apud cell tumor
- Tumors leaping into the liver
- Rare benign lung tumor
- Leukemia

It is also high in pregnancy and newborn babies.

How is calcitonin elevated treated?

If you suspect high calcitonin, you should go to an internal medicine specialist. Your calcitonin height will be determined by the tests that your doctor will give you.

GASTRIN RELEASING PEPTIDE (GRP)

GASTRIN RELEASING PEPTIDE (GRP)

The functions of GRP are those:
- Neurocirculating hormone
- Tissue-specific growth factor

Increasing evidence suggests that BLPs and GRPR may play a role in CNS disease, including memory disorders associated with AD and other neurodegenerative disorders.
According to some researchers,
- GRPR (GRP Receptor) is considered as a target for the treatment of cognitive dysfunction.
- GRP plays a role in brain plasticity.

GRP is a signal chemical released during emotional events in the brain.
In mice, GRP has been shown to help control fear response and GRP deficiency can lead to larger and more permanent feelings of fear.
It has been reported that hormones such as cholecystokinin, bombesin, gastrin-secreting peptide, neuromedin B and glucagon secreted from the digestive system produce saturation signals, and therefore, their nutrient intake is controlled by their influence.

additionally....

Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide

Neuropeptides and anxiety disorders: bombesin receptors as novel therapeutic targets

CANNABINOIDS

Let's begin with a beautiful song and a clip.

2-ARACHIDONYLGLYCEROL

In response to an increase in intracellular calcium levels, it is synthesized mainly in cell membranes and often functions as a full agonist.It is believed to be a messenger molecule that regulates the transmission of signals between synapses in the brain.During fasting, 2-AG increases in hypothalamus and limbic forebrain .2-AG is adaptogenic for the brain against stress and has an important role in anxiety. Less 2-AG more anxiety and depression.2-AG is especially consumed in the amygdala and this prevents the adaptation process to repeated stress. This molecule, ending blockade of CB1 receptor, suppresses glutamate release, which should be considered as good news.
(The CB1 receptor is mostly located in the brain and spinal cord. It is responsible for the characteristic, physiological and especially psychotropic effects of cannabis.).Regarding cannabinoids found in hemp, researchers found that THC binds to both CB1 and CB2 receptors and activates them like an endocannabinoid. CBD does not bind directly to cannabinoid receptors. CBD is responsible for the breakdown of the body's most important endocannabiniodi, anandamid. It works by blocking an enzyme called FAAH. When FAAH is inhibited, it cannot break down anandamide normally. This causes anandamide to accumulate in the brain, allowing us to use it more effectively.

What is cannabinoid?
A cannabinoid is a naturally occurring compound found in various plants, especially Cannabis sativa . Of the 480 compounds found in hemp, 66 are thought to be cannabinoids. Cannabinoids are lipid-based molecules that act to some degree on cannabinoid receptors, the main component of the endocannabinoid system.

There are three types of cannabinoids, as follows:

Phytocannabinoids: Cannabiodes produced by plants.
Endocannabinoids: Cannabinoids produced from the human and animal body.
Synthetic cannabinoids : Cannabinoids produced in a laboratory.

The most commonly used cannabinoids (classical cannabinoids) include THC, CBD, THCV and CBC. The biggest difference between cannabinoids is that they are psychologically active. CBD accounts for about 40 percent of hemp resin, and THC is the only plant cannabinoid that produces a clear psychological effect on its own. There are also cannabinoid receptors CB1 and CB2. In the past few years, some other non-cannabinoid plant components have been reported to bind to and functionally interact with these CB receptors .

Health benefits of cannabinoids
- Reduces anxiety
- Reduces inflammation and pain
- It controls nausea and vomiting caused by chemotherapy
- Kills cancerous cells and slows tumor growth
- MS (Multiple tissue stiffening) relaxes patients' tight muscles
- Increases appetite and helps people gain weight with cancer or AIDS

8 herbs that are not hemp but contain medicinal cannabinoids

1. Echinacea Purpurea

This herb that strengthens the immune system is also used to relieve anxiety, fatigue, migraine and anxiety. Unlike cannabis, it uses cannabimimetry instead of cannabinoids to switch to the endocannabiniod system.
Cannabimimetrics are a set of non-classical cannabinoids that mimic the biological activity of classical cannabinoids (although they do not share their structure). N-alkyl amides (NAAs) in echinacea are responsible for regulating the immune system, pain, and inflammation.