Anandamide: A Neurotransmitter Affecting Happiness

   BLISS MOLECULE ANANDAMIDE 

 

The effects of anandamide are short-lived and very intense. For this reason, it positively affects different parts of our brain and body.Anandamide is a compound our body produces. Interestingly, it has properties very similar to THC, an active ingredient in cannabis. So, most people say that this neurotransmitter is the "natural cannabis" produced by the human body.

   Anandamid has a cannabis-like effect. It is very relaxing and stabilizes and regulates the cardiovascular system. It also gives a sense of happiness. In fact, the word comes from the word "ananda", which means "carrying peace and inner happiness" in the Sanskrit language . This is in the human body and chocolate.

   Scientists discovered this substance in 1992. They described it as a weak molecule with a short-term effect on the body. In addition to its sedative effects, it improves the work of the respiratory system and affects cognitive functions.

"Happiness usually sneaks in through the door you don't realize you're leaving open."

– John Barrymore

How does Anandamide work?

   The brain synthesizes anandamide. It works in areas related to memory , advanced cognitive processes, motivation and motion control. Scientists have discovered that this substance can reduce the pain sensation. In addition, it can interfere with appetite, reward and pleasure feelings.

   Researchers did a study on mice in 2017. Scientists injected a dose of anandamide into mice. The behavior of the mice changed after this procedure. When they faced cognitive problems, they were more interested in finding a solution and were more able to do so.

   Some people think that science has not yet been able to detect all the features and effects of this neuronstant. Some argue that this may be a good healing aid tool for psychoactive addicts. However, there is not enough evidence to support this.

Effects of Anandamide

 

The effects of anandamide are short-lived and very intense. For this reason, it positively affects different parts of our brain and body. Its main effects are:

Homeostatic. Anandamide supports the regenerative properties of the body and stabilizes the nervous system.
Analgesic. Similar to cannabis and all similar cannabionides, it has strong pain-relieving effects.
Neurological protector. It helps regulate the stimulation process in the nervous system, producing protective effects.
Appetite regulator. Studies have proven that anandamide regulates appetite and saturation cycles, while at the same time changing the feeling of hunger.
Antiemetic. This means it helps prevent vomiting. To do this, it cooperates with serotonin.
It regulates sexual desire. Research shows that a small amount of anandamide stimulates sexual desire . However, taking it in high amounts reduces sexual desire.
It has a role in pregnancy. This substance has a role in interfering with the embryo in the uterus.
It is naturally motivating. It improves decision making and increases self-confidence.
Cognitive functions. Anandamide helps establish new neuronal connections. This supports thinking, learning and memory processes.
Rest and well-being. It makes you feel peaceful, relaxed and happy .
Anticarcinogenic. This effect has not been proven yet. Everything indicates that cancer cells are preventing the growth of cancer, especially melanomas.

How do we increase anandamide level?

   The simplest way to increase the anandamide level is to eat dark chocolate. This nutrient contains a significant amount of theobromine.

   Scientists assume that this substance stimulates the production of neurotransmitters in the brain. Dark chocolate contains a large amount of theobromine. However, if you chew the cocoa shell, its effects will be much greater.

   In addition, a team of German researchers conducted a study on this topic in 2015. In this study, they realized that exercise facilitates anandamide production. Therefore, they concluded that this neurotansmitter, not endorphine, is responsible for producing a sense of happiness after physical activity.

   In addition, black truffles are naturally found in anandamide. Likewise, scientists have recognized that meditation contributes to the natural production of various substances, such as anandamide, serotonin, dopamine, and endorphine .

ACETYLCHOLINE

   ALONE COWBOY :ACETYLCHOLINE

   You are probably familiar with the name acetylcholine. It was discovered in heart tissue by Henry Hallett Dale over 100 years ago. Then Otto Loewi showed that it was a neurotransmitter. Both scientists were awarded the Nobel Prize. As acetylcholine is the first neurotransmitter discovered , it has a special place in our hearts.

   The places where acetylcholine functions are not limited to brain tissue. Besides neurons, it performs very important tasks in muscles and glands. It takes its name from its chemical structure: ester of acetic acid and choline molecules. If you hear the cholinergic name somewhere, know that acetylcholine is mentioned. For example cholinergic neurons . These neurons communicate by using acetylcholine. It has an important role in the communication between motor neurons and muscles. The secretion of acetylcholine from neurons stimulates the striated muscles and ensures their contraction. Therefore, drugs that can affect the cholinergic system have very dangerous effects. It can also put you in chills of tremor or paralysis.

How is acetylcholine produced and secreted?

   The choline acetyltransferase enzyme is key in the production of acetylcholine. Production of acetylcholine continues in certain neurons after the necessary components are provided. This neurotransmitter is not carried back into the cell, such as serotonin or dopamine . It is used and recycled. This task is assumed by the enzyme acetylcholinesterase. If this enzyme does not work, many muscle problems occur. Some toxins can block this enzyme from working, causing paralysis and even stop breathing. The heart muscles may not work and the heartbeat may stop.

   So far, we have focused on the vital duties of acetylcholine, but it has many more functions in both the brain and the body. Acetylcholine acts in the central nervous system and the peripheral nervous system. It is found in many areas in the brain, from the basal forebrain to the cerebral cortex and the hippocampus . Acetylcholine also has a role in cognitive functions, as neurons in the frontal region of the brain concentrate on cognitive functions. In the peripheral nervous system, as mentioned above, it affects the muscles and glands. It is one of the staff of the autonomic nervous system, as most muscles in the body can penetrate .

Acetylcholine Receptors

   You came home from work in the evening, you are very tired. You want to enter the house and lie down on the sofa right away. When you come to the door of the house, you realize that your key does not fit in the lock. It turns out that you got the keys to the summer house in the morning. Cellular-scale active substances also work according to the key lock principle. No matter how much acetylcholine you have, it won't work if you don't have the proper receptor. There are several types of receptors to which acetylcholine binds. These are basically called muscarinic and nicotinic .

   Nicotine, as you know, is a substance in tobacco. Muscarin is also found naturally in Amanita muscaria mushrooms. The names of the receptors are given because these chemicals activate them. Nicotine receptors are ion channels. The binding of acetylcholine to these receptors allows ions such as sodium, potassium and calcium to enter the cell. These receptors are found in both muscles and neurons. Muscarinic receptors affect the intracellular signaling mechanism. It initiates the signal chain, which allows the cell to be stimulated and stopped according to its type.

What are the substances that block acetylcholine?

   We briefly talked about the functions of acetylcholine in the brain and body. It plays a role in cognitive functions in the brain, especially in the forebrain. But perhaps its most important task is to stimulate the muscles to contract in the body. If this molecule does not work properly , problems such as stroke and chills occur . Even breathing and cardiac arrest can be seen. The acetylcholine mechanism does not stop easily, but there are some things blocking it. For example, antibiotics such as clindamycin and polymyxin are problematic. Magnesium prevents acetylcholine from working because it inhibits P-type calcium channels. In addition, hypocalcemia, diuretic drugs and Botulinum toxin damage the mechanism.

PANDEMY AND PSYCHOLOGY

Physical and Spiritual Scars Emerge by SARS Outbreak When Coronavirus Panic Surrounds the World
 

10 years ago, the traumatic wounds of the SARS virus, which affected 8422 people and killed nearly 1000 people, still affect the survivors.
  Ten years ago today, residents of Amoy Gardens in Hong Kong were unaware that they would be newspapers  headline when they wake up in the morning. Cases of severe acute respiratory syndrome (Sars) occurring in Kowloon Bay were increasing one by one. A quarantine was declared, but 42 people were already died in the outbreak.

The long-term effects of the SARS virus continue, both physiologically and psychologically.


   For many experts, survivors of SARS are still obliged to live with fear of depression and epidemics today. Especially as the coronavirus epidemic continues to wrap the world slowly ...

 

Doctor Ivan Mak Wing-chit, who treats SARS sufferers, explains:

"These times we're in are particularly difficult for these people. One of my patients explained that he felt depressed because of seeing the news of the 10th anniversary of Sars. He tired of living with the fear of these memories."

The most 'deadly place' in the city at that time was the Prince of Wales Hospital in the city of Sha Tin. Many healthcare professionals and patients were exposed to the virus here.

Kim Yuen, who traps a virus from a nurse, explains:

"Then I was about 60 years old. I was in isolation for more than 100 days. It was the first time in my life that I felt so lonely. Suddenly I was left alone in fear and panic because of my illness."
"Every breathing I had was another challenge. I was thinking if I could take the next breath in my head. It was as if I was abandoned there without anyone around me, pain and fear were unbearable."

In the same hospital, close the virus Prof. Dr. Henry Chan explains that the disease has darkened his life.

Both patients were lucky because they were treated, but post-traumatic stress disorder problems remained. Others have developed anxiety disorders, stress, and hypersensitivity to these memories.

According to a study conducted after 2 years after the epidemic, where uncertainty and fear prevailed, 40% of patients recovered after SARS experienced post-traumatic stress disorder.

This figure is even more than natural disasters before!
Again, according to another doctor working in the same hospital, while these patients experience fear even in the smallest health problems, this coronavirus outbreak drags them to great panic.

Doctor Mak is trying to overcome these traumas by visiting the Amoy Gardens region with the patients.

Dr. Leung Chi-bong working in the same hospital at that time explains that his colleagues are also affected by the situation, that he is alone, and that fatigue and panic affect them very deeply.

"We had to eat our meals facing the walls, not face-to-face. The hospital was cold and quiet, nobody was talking to anyone. Then, as we got to know the virus, we returned to normal, but this time we were putting cardboard between us. But at least we could chat."


Still, there are dozens of volunteers who want to work in the hospital in this mess!


It is not yet possible for scientists to reach the level of the Sars virus, but panic and fear continue to spread.

another poem
one day, to my surprise,
human would forget
even his lover's eyes.
with tired voices
when clocks pulse
at twenty all the nights,
don't you forget
about me.
Because I
live and think about you
every night at that time.
And I desperately dream of you.
Please don't you forget
about me,
where the darkness ends.

TRACE AMINES IN BRAIN

1-OCTOPAMINE

 
Octopamine has roles;
- In controlling various behaviors such as learning, memory, or aggression and has a wake-promoting effect.
- As tyramine, epinephrine and norepinephrine monoamines in invertebrates.
 
   Octopamine may promote lipolysis and weight loss and has stimulating effects.





2-SYNEPHRINE

 

Synephrine use stimulates the effect of alpha 1 and alpha 2 adrenal receptors, but this is significantly less than phenylephrine and ephedrine.
   The use of Synephrine also leads to increased activation of neuromedin U2 receptors (molecules in the hypothalamus that increase alertness). These molecules are located in the hypothalamus in the human brain and are responsible for controlling sleep. The use of Synephrine will stimulate the hypothalamus receptors that cause wakefulness longer than normal.




3-TYRAMINE

 

    It is the trace amine that increases the blood flow of the brain and also strains its vessels.
   It is the item that we owe the so-called migraine disease (the only reason is not this element, but 30%).
   It is destroyed by the enzyme mao a.
   Fermented food is abundant in products.
  Cheese, wine, etc.
  I don't know how many times you can eat in your life.
  But it is said that there are too many in foie gras.




4-PHENYLETHYLAMINE

   It occurs naturally in the nervous systems of humans and other mammals and acts as a neurotransmitter (inter-nervous chemical transmitter) or neuromodulator (regulating various populations in the nervous system).
   Phenylethylamine, which has a stimulating effect, has an important role in the neural chemistry of romantic life, such as love. It causes the secretion of noradrenaline and dopamine in the human brain. There are many derivatives of phenylethylamine used for medical or recreational purposes.
   The most familiar and most important role of phenylethylamine leads to the release of high amounts of dopamine and noradrenaline in situations such as emotional attachment and love.
   Dopamine is a chemical substance with a sympathetic effect in the central nervous system and especially in the basal ganglion cells. It has a significant connection with human-driven sexual impulses. Noradrenaline also causes increased attention and increased heart rate. These chemicals are directly related to the formation of feelings such as sexual passion, romantic relationships, happiness and nervousness.
   It is estimated that consumption of foods with high levels of phenylethylamine, such as chocolate, is similar to these effects. In fact, women who are depressed among the public consume a lot of chocolate. Similarly, drugs containing neurotransmitters are offered for sale to lose weight or put people in a certain mood.
   However, the high amount of phenylethylamine consumed through the digestive system is metabolized very quickly to reach the brain. Therefore, phenylethylamine taken as a food, medicine or supplement is unlikely to have a therapeutic effect. People with conditions such as attention deficit, hyperactivity, or clinical depression often take a low amount of phenylethylamine, while schizophrenic patients use it in high amounts.

3-TRYPTAMINE

 

 A kind of monoamine alkaloid. Triptamine acts as a neuromodulator and vasoactive agent in the human body. There are many relatives of triptamine, which can be found in the brain and functions serotonergically. Decarboxylation product of tryptophan, which occurs under the influence of microorganisms in the intestines. Interesting substances, from serotonin and melatonin to psilosibin and dimethyltriptamine, are triptamine derivatives. Huh the triptamine itself is not a psychotropic, it's interesting.



3-Molecule Combining Spirit and Body: Dimethyltriptamine (DMT)

    Dimethyltryptamine (DMT) is a substance found in all living things without exception. Every living creature either secretes DMT or lives with DMT.
    Dimethyltryptamine, or DMT, is secreted during sleep by the pineal gland around the brain. N, N-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD) -like serotonin agonist is a hallucinogen. Its secretion coincides with the stage in which dreams are seen, and the biggest effect of DMT is that it causes errors in perception of time.

    Every part of our brain is symmetrical; so there are two of all sections. The only exception is the pineal gland, which is located in the middle of the brain and is a single one. The pineal gland, also known as the pineal gland, is a lentil-sized gland located in the brain of vertebrates. Pineal gland is a cone-like structure. Its English name is “pineal gland,” which means cocolax gland. The symbol of the pineal gland has inspired many religions. The cone in question is; In the minds of Buddha representations, you can find many more places in the cone sculpture in the Vatican.

“Descartes, considered the father of modern philosophy, thought that the pineal gland is the point where the soul meets the body.”

    DMT is found in humans, plants and animals. It is produced exactly in the upper part of the DMT pineal gland in our body. It is most commonly secreted at the time of birth and death and is very effective on human consciousness. So much so that it is called the hormone that allows the soul to enter and exit the body. DMT secretion increases slightly during sleep. The main thing is the increase in the secretion of DMT in the moments of birth and death. During birth, both the mother and the baby's DMT secretion increases. DMT is actively transported through the brain barrier.

    Ayahuasca is a very powerful hallucinogen drink obtained by boiling the branches and leaves of the Banisteriopsis caapi plant. Due to the dimethyltryptamine (DMT) it contains, it is illegal to use in most countries except medical obligations. In fact, he has been known in the Amazon Forests in Peru for centuries as the vine of ayahuasca, is consumed by the Cobino Indians, and is collected by shamans and mixed with various herbs and drunk. The name in that region is already "Shaman Elixir". Ayahuasca is a poisonous plant species and its excess consumption can easily kill a person.

PURINES AND THE BRAIN

 NEUROTRANSMITTER PURINES

   1- ADENOSINE

When we are awake, a chemical called adenosine accumulates in our brain. And this hormone binds to receptors that slow down the activity of the brain. Finally, the more adenosine accumulated at those receptors, the tired the brain will feel more. The longer we stay awake, the more we feel tired.
   On the other hand, adenosine intensity decreases during sleep. This slowly increases alertness. The structure of adenosine is very similar to that of caffeine in the coffee we drink. Therefore, when caffeine passes through your circulatory system and goes to the brain, it binds to receptors by competing with adenosine there. But since caffeine isn't actually adenosine, you won't feel sleepy and adenosine can no longer bind to receptors and so its calming effects are reduced.

   Adenosine, a purine, is normally found in the brain at low concentration. It inhibits the spontaneous and increased activity of many neurons in the brain. Many years ago, adenosine has been found to have a calming effect on animals. Bob McCarley, who works at Harvard Medical School, has revealed that adenosine plays a major role in sleep, especially in sleepiness. When Bob McCarley and his friends kept the cats awake by playing games, they found in the forebrain that there was increased adenosine outside the cell, and when they allowed the cats to sleep, the adenosine gradually returned from high levels to normal levels.
   The researchers also found that giving adenosine to the basal forebrain made the animals sleep. Adenosine may be below the perceived weakness caused by lack of sleep. According to the findings of Robert Strecker, McCarley and colleagues from Harvard Medical School, a disturbance was detected in the attention test performed by injecting adenosine into the basal forebrain of mice. However, it is not right to think that adenosine levels are the main reason for sleep deficiency in terms of effects on the brain and body.
NOTE: Dipyridamole is a reuptake inhibitor of adenosine.


  2-Nicotinamide Adenine Dinucleotide

   

NAD or "Nicotinamide Adenine Dinucleotide"; it is a naturally occurring niacin enzyme that helps cells in our body produce energy. Like the lack of oxygen and glucose, NAD deficiency leads the cell to death. It converts the energy we take from food into cellular energy.It increases the cell's energy level and increases the cell's resistance to disease. It increases the defense mechanism of our body as much as possible.
   NAD increases your body's serotonin levels, a neurotransmitter associated with mental regulation, and can improve symptoms of depression and anxiety.

   NAD is beneficial for individuals treated for substance abuse and addiction recovery. This treatment reduces the desire for substance use and withdrawal symptoms, energizes the body and accelerates brain regeneration.

   Among other functions, NAD plays an important role in delaying aging. NAD works on the energy-producing element of the cell, the mitochondria, and increases the length of telomeres, which are protective caps, located at the ends of the chromosomes, which become shorter as the body ages.

   The body naturally produces NAD; however, the overall levels of coenzyme decrease over time, leading to cellular changes that lead to age-related pathologies. If the NAD level is sufficient, DNA is protected from damage.

 

 Post-traumatic stress
   Worry
   Depression
   Brain damage caused by various reasons
   Alzheimer's
   Parkinson's
   Cancer
   Neurodegenerative diseases (such as ALS, brain cell loss… etc)
   Using alcohol and drugs
   Aging… etc
   For the reasons I mentioned above, the amount of natural NAD decreases. In this case, our body cannot produce enough energy and diseases and NAD deficiency begin to destroy cells.

   NAD Therapy provides more mood and awareness by energizing the individual. It has also been claimed to slow the aging process. In addition, with the received NAD, the quality of life of the cells improves and the DNA that manages our body is saved from harm. NAD treatment, the main purpose of which is to protect the person from diseases; ALS, whose treatment has not yet been completed and has not ended with healing, is used as an adjunctive therapy in diseases such as degenerative brain disease, cerebral palsy, diabetes. The aim is to increase the amount of energy; to reduce the harm of cells and prevent death.

3-ATP 
   Much of the ATP energy is used in cytosol to preserve ion gradients from the membrane and support the cycle of neurotransmitters, thereby pumping sodium and potassium through the cell membrane to support electrophysiological activity and cell signaling in the brain. ATP metabolism, which regulates both ATP production and use, plays a key role in cerebral bioenergetics, brain function, and neurodegenerative diseases.

GASOTRANSMITTERS

Resim yazısı ekle

GASOTRANSMITTERS

1- Nitric oxide 

   This composition, which many people have heard of several times throughout their life but does not know exactly what it is, is one of the most important substances that lead to the continuation of human life. Nitric oxide (NO); It is defined as a colorless, poisonous gas obtained by oxidation of nitrogen. It is a molecule that consists of a combination of a nitrogen and an oxygen atom.
Extensive research over the past two decades has revealed that this molecule plays an essential role in intercellular communication. Nitric oxide is a hormone naturally produced in the human body, a chemical messenger; It plays a strategic role in the regulation of vital functions of the nervous, circulatory, defense, respiratory and reproductive systems.
   So, what does the effect of this molecule bring people?
   The answer to this question has been very short and clear. Survive…
   Because nitric oxide plays a regulatory role in the work of our brain and heart, our two vital organs. It performs its regulatory role by ensuring that the blood flows smoothly in the veins and flows comfortably through all our organs. Thus, the risk of brain bleeding and heart attack decreases as it regulates and relaxes the blood flow.

PROS
Neuroprotective Effects
- iNOS inhibition
- Inhibition of peroxynitrate anion that maintains mitochondrial respiration.
- Impede cytochrome C and maintain cellular physiology.

CONS
Neurodegenerative Effects
- eNos activation and increase in intracellular calcium level.
- nNOS dephosphorylation
- Superoxide anion formation.
- Oxydative stress.

2- CARBONMONOXIDE

  It is a colorless, odorless, toxic gas formed by the combustion of carbon with insufficient amount of oxygen. There are headache, visual disturbances, drowsiness, confusion and coma in the poisoning table. Judicial ability is impaired and intuition is lost. As a result, permanent brain damage may occur. Also, neurasthenia, depression can be seen. Significant recovery may follow encephalopathy secondary to oxygen deficiency. Organic psychosis can last for months, but the end ends relatively well. Its treatment is done by giving 70% nitrogen and 30% oxygen with a mechanical breathing tool or by mouth breathing in emergency situations. It is used in generator gas, water gas, force gas and air gas in the industry. It is also used as fuel. It is also found inside the cigarette.
   Also, in the event of brain damage, carbon monoxide has been proven neuroprotective in many animal models.
   Inhalation of CO ... Recent studies have revealed that Inhalation of CO  can be an important treatment for sicks and can be used to treat neuropathologies, psychiatric diseases, and neurodegeneration. Clinical studies have revealed that CO is necessary to get rid of patients' diseases.

PROS
Neuroprotective Effects
-Exogenous injection increases survival of dopaminergic neurons.
- Redox control and modulation of proliferation.
- Decrease generation of TNF-alpha

CONS
Neurodegenerative Effects
-Upregulation of heme oxygenase
-TNF-alpha generation and mitochondrial malfunction.
-Oxidative stress, formation of ROS and RNS.


3- HYDROGEN SULFIDE

   It is a stench, colorless gas that resembles the spoiled egg smell. It is a very toxic gas that irritates the respiratory system and lungs, but it has an effect on the central nervous system It has many regulatory functions in the physiological system, such as a kind of neurotransmission and neuromodulation, and is considered an important signal functional molecule fragment, which is associated with learning, memory and nociception.

PROS
Neuroprotective Effects
- Inhibit oxidation of lipid and protein peroxidation.
- Inhibit proinflammatory molecules such as cytokines and chemokines.
- Inhibit TNF-alpha expression.

CONS
Neurodegenerative Effects
- Homosistein
- Central atrophy, seizure, intellectual impairment.
- Microglial activation and neuroinflammation.

ANTIDEPRESSANTS,BUT...

 

Not everyone with depression is melancholic. So antidepressants are not the only way to affect the communication between neurons. Still, ignoring mood regulators' very successful functions to save lives can be a devastating mistake. However, these pills have one major drawback. Will it affect and how long it will be, even if it will.
   And that's not all. Which dosage can be effective is a problem in itself. I talk for myself, I used 200 mg sertraline for years, but it only showed a limited effect. And I used a lot of other drugs after sertraline, but they didn't work and I found myself being pushed towards melancholy day by day. Finally I tested the bottom point. Then, according to some people, as a result of a complete coincidence, but to me as a manifestation of destiny , I unconsciously received a higher dose of sertraline.
   And what 'appens?
   A mani-like picture appeared
   This was an impossible recipe for someone suffering from depression. Now I am wondering why my doctors, who have been studying medicine for years, have never thought of this?

NEUROTRANSMITTERS-AMINOACIDES

  ARGININE

   The link between arginine and depression is simply as follows:
   Major depression reduces the bioavailability of arginine. For this reason, the body cannot produce enough nitric oxide and may cause depression to resist treatment as a result of increased inflammation. Unfortunately, it does not seem possible to increase bioavailability with the supplement of arginine.
   Although there are users who indicate that their mood improves significantly by taking this nutritional supplement, there are not many uses other than lowering blood pressure and effectiveness in erectile functions.

GABA (Conversely GLUTAMATE)
Another Name of Calmness and Relaxation

 Gamma-aminobutyric acid (GABA) is an amino acid and neurotransmitter that regulates excessive excitement or fussing of the brain by preventing the ignition of too many neurons, thus making us feel calm. As a restrictive neurotransmitter, the main function of GABA is to slow down brain activity.
   It is especially adept at reducing unwanted thoughts that nourish stress, anxiety, depression and other psychiatric disorders.
   Another issue that GABA affects brain functions is related to the change of brain waves. The availability of this substance in sufficient quantities leads to an increase in brain waves associated with calm status (alpha waves). In addition, a decrease happens in brain waves associated with stress and anxiety (beta waves).
   In order to better understand the functioning of gamma-aminobutyric acid, we need to ignore another neurotransmitter, L-glutamate. This neurotransmitter is a natural byproduct of energy produced in the brain. In other words, this very important neurotransmitter is one of the products that result from the metabolism of glucose in the brain. These two neurotransmitters are opposite and complementary. While GABA slows down brain activities, on the contrary, glutamate increases these activities.
   GABA and glutamate not only work together, they also have the ability to transform into one another.

Supplements to Increase GABA

1) Picamilon (can cross the blood brain barrier)
2) Phenibut (Very effective but long-term use leads to addiction. Although it may seem dangerous, its use as a short-term and last resort in emergency situations can save lives.)
3) Kava Kava
4) Magnolia Bark
5) Valerian
6) Scutellaria baicalensis
7) Melissa officinalis
8) Nigella Sativa
9) Jasminum officinale
10) Ashwagandha ( Withania somnifera )
11) Lavandula
12) Theanine
13) Apigenin
14) Green Tea ( Camellia Sinensis)
14) Taurin
15) Salvia miltiorriza
16) Cussonia zimmermannii
17) Curcuma zedoaria
18) Cyperus rotundus
19) Exercise

ASPARTATE

   Since the human body can synthesize the aspartate it needs, it is not vital to take it with food from outside. Although it has been suggested that aspartate, which is used as a neurotransmitter, can provide resistance against fatigue and increase endurance, the experimental records supporting this are not very strong.
   Aspartate accumulation causes excess calcium to enter the cells, causing neuron death. It also triggers an excessive release of free radicals.
Note 1: Aspartate is used to create body hormones and support the normal function of the nervous system. Naturally found in legumes, nuts, meat, eggs and salmon.
Note 2: Although there are contradictory statements about the harm of aspartame, 40% of which contains aspartate and is used as artificial sweetener, I have a deep prejudice that it is really harmful. The decision is yours.

GLYCINE

Glycine is the smallest and simplest of all amino acids. By contributing to the neural communication in the brain, it improves sleep quality and eliminates energylessness by minimizing fatigue.
While glycine can play both suppressive and stimulating roles, it has an important place in the transmission of nerve signals. In this way, it contributes to cognitive flexibility and the proper formation of memory-related structures.
This amino acid has a calming effect on the brain and can help us fall asleep and sleep by lowering body temperature.
Studies with people that have sleep problems have shown that taking 3 grams of glycine before bedtime reduces sleep time, improves sleep quality, reduces daytime sleepiness and improves cognition.
Note: Glycine may impair sleep quality in healthy people.

D-SERINE

Its increase in the hypothalamus after the D-Serine injection indicates that it has probably crossed the blood brain barrier.
It is thought that it may cause a decrease in the feeling of fear 2 hours after taking.
Although it has positive effects on memory since it increases glutamineergic nerve conduction, it has the potential to reverse the desired effect in major depression. Therefore, I take a dim view of using it as a nutritional supplement.

I explain the true cause of the corona virus!

ADVERTORIAL


NOTE ON HISTORY

- This virus does not kill.
- By creating panic and chaos, people are closed to their homes.
- Everyone tends to blame the United States, claiming that it produces the virus.
- The US apparently knocked China out with a $ 5-10 virus, but the U.S. Congress approved a $ 7.8 billion budget to fight the virus.
- The virus attack was carried out by globalists in America, not America.
- It is not naive to expect China to emerge stronger after this attack.
- The most suitable place for this epidemic to occur was China. The only fault of the Chinese is that they live in China.
- USA will been left holding the bag.
- The flow of capital to China will accelerate because the United States is having difficulties in the transition to digitalism.
- This virus was not produced to reduce the human population but to break the link between the old and the new generations.
- It is a fact that more than 80% of the people killed by the mutated virus consist of people aged 65 and over.
- Why? Grandfather and grandmother means history, religion and culture.
- But in the new order planned, that is, in the age of transhumanism, there is no room for 20th century habits.

Technology Changes Sociology.

-All organizations where people can go for religious purposes are canceled.
-While the workplaces where robots are employed continue production, people are directed to work from their homes.
-Delivery of the orders they make for their needs will be done by robots.
-Payments and salaries are already made online.
-Nowadays, where even confession can be done online, I think it is not strange that worship can be done online thanks to augmented reality technology.

Virus Everywhere.

-It will be inevitable for all major international organizations and companies to get acquainted with the virus. (Amazon, Facebook, Nato...)

Transhumanism

- The corona virus is just a social experiment for the realization of the 4th industrial revolution.
- Societies are forced to be digitalized.
- With digitalization, individuality is brought to the fore by eliminating contact between people.
- What will the individualized person deal with at the computer?
      1. Artificial intelligence
      2. Augmented reality
- With augmented reality, heaven will be promised to those who stop their visiting to the ground.

Result
- But the earth will also have an answer to these plans.
- I'm not afraid, you?

Scheme of All Known Neurotransmitters

                

"Hour Hands" and "Minute Hands" in Our Brains... Melatonin

   SEROTONIN TO MELATONIN

What is the difference between waking up in a dark weather and waking up in a sunny weather? Could this difference be related to a watch inside us? Have you ever thought that this watch may have related to depression ?

"Hour Hands" and "Minute Hands"

   The human body also has a cycle of about 24 hours called circadian rhythm. A brain structure called suprachiasmatic nucleus (SCN) is responsible for this cycle. Our SCN sleep cycle is associated with the release of cortisol hormone, which we know as body temperature, growth hormones, stress hormone. We can think like a clock that determines "what" will be secreted "when".
   1. The tickers of this watch are related to whether some proteins are activated or not.
   2. The light signals from the eye send a number of warnings directly to the structure we call this SCN.
   Thus, this system becomes active or not according to the amount of incoming light. In other words, when daylight is born, our biological clock starts activities that will awaken us.
   But if we wake up at a time when there is no daylight, we will have trouble waking up because the brain still cannot receive the signal to start activities that will wake it up. The same system makes us ready for sleep by starting some activities after daylight is gone. SKN is responsible for the release of a chemical called “melatonin” around 21.00 - 22:00 by sending some signals to the pineal cloth known as the third eye of our body.
   Melatonin is a chemical that is secreted only in the dark, has a sleep-inducing, lowering body temperature. Especially at night between 23:00 and 05:00, melatonin secretion peak and its concentration in the blood increases 3-10 times.
 
Within an inch of Depression

   In winter, the daylight diminishes, with more exposure to the darkness, and a fluctuation in the circadian rhythm of the body and in the amounts of melatonin. As a subtype of depression due to the genetic predisposition in some people may experience Seasonal Affective Disorder (MeDB);

- Starting in winter and autumn, ending in spring,
- Accompanied by an increase in appetite and weight gain, including carbohydrate-weighted nutrition,
- Excessive sleep (hypersomnia),

  Also known as “winter depression”. There is an increase in their amount of melatonin during the day. Melatonin, on the other hand, acts as a chemical that initiates energy-gathering activities. Thus, it triggers the mood of sleep and eating, revealing the symptoms of winter depression. MeDB was more common in people who live in high-latitude countries such as Canada and Norway and are less exposed to light in winter than low-latitude countries.


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Serotonin Precursor Tryptophan

 

Serotonin is an amino acid derived neurotransmitter and is synthesized directly from the tryptophan amino acid. If tryptophan is absent, serotonin cannot be synthesized and no matter how much sugar you take, your nerve cells will break down protein. Tryptophan, one of the resulting amino acids, will also be used for the synthesis of serotonin. In other words, if we need to make a headline like newspaper news, we can say: "Don't be happy, being happy is breaking your proteins".🎭😪
 

 That is the tryptophan amino acid you see. The upper one of the rings is the indole ring and pay attention to this ring.

 

 What you see is serotonin, which is responsible for happiness. Look carefully at the left of the 2 rings.

   As you can see, serotonin is synthesized from tryptophan. Your body can only form this indole ring by detaching it from tryptophan. So if you don't get enough tryptophan amino acids, you can't be happy, and if you consume foods rich in tryptophan amino acids, you can be happy. The proof of this is the following.

   Yes, the reason why chocolate makes you happy is that it contains richly tryptophan amino acids in its structure. In this way, you take lots of indole rings and synthesize serotonin from this ring.

How to Increase Serotonin Naturally?

How to Increase Serotonin Naturally?

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Serotonin...May God never take you from our brain!

 A small amount of the hormone serotonin in the brain can lead to depression and similar problems. When serotonin is secreted in the brain, blood vessels contract and contract. As the level of serotonin decreases, they expand again. Insomnia, the desire to eat carbohydrate foods, anxiety, decreased mental function, weakness and fatigue, digestive problems, increased sexual desire but decreased ability to establish emotional relationships can be indicators of low serotonin. Excessive amounts may cause a high level of nerve activities, resulting in a fatal outcome. This condition is called serotonin syndrome. In migraine attacks, it was determined that serotonin level was high and decreased after migraine attack passed.
   In all our moods with ups and downs,  we are not guilty, in fact, our serotonin levels. If it finds the balance, we will be in peace but in any way it's going to bear down on us.😪
   Despite its relatively simple chemical structure, serotonin plays a complex role in biological systems. Again, high serotonin activity reduces appetite. This activity is stimulated by carbohydrate intake. Therefore, it is thought that there is a relationship between obesity and low serotonin activity.
   Serotonin deficiency may occur for three reasons: low production of brain cells, insufficient receptor sites, or deficiency in the tryptophan substance used to make serotonin. Although it is generally accepted that serotonin deficiency plays an important role in depression, it is not possible to measure the level of serotonin in a living brain. Therefore, there is no study to prove that depression or a mental disorder is a deficiency of serotonin or other neurotransmitters. However, the level of serotonin in the blood can be measured, and when this ratio is measured in patients with depression, the level of serotonin has been found to be lower than other people (of course, serotonin levels in the blood and brain may differ).

   Serotonin and Sleep

Despite the 21st century, sleep is still not fully understood. But serotonin definitely plays an important role in the sleep cycle. High levels of serotonin are associated with wakefulness and low levels associated with sleep. Along with melatonin, serotonin controls the circadian clock and is affected by daylight. As daylight serotonin level increases, melatonin decreases.
   The neurons that produce serotonin are active during wakefulness, and the serotonin and rafe core trigger sleep. These results create a paradox. How can serotonergic neurons active while awake cause sleep?
   As a result of all this, I hope that more questions will appear in your mind rather than answers, and I think the beauty of science is here. An endless curiosity…
 

Chemistry of happiness-Dopamine

   Dopamine, an important source of strength for our brain, is one of the indispensable elements for our body. Why? Because it is a chemical substance that has the task of transmitting signals from the body to the brain and is naturally found in our body. Another information that we should mention as the answer to the question of what is dopamine is the effect of this chemical on the emotional reactions and movements of the person. A possible reduction in quantity, that is, dopamine deficiency can lead to many serious problems, from depression to Parkinson's. Also, what is dopamine is a chemical that has a direct effect on the center of learning and information storage processes. Accordingly, the level being balanced means having a good memory and gaining easy learning skills. Dopamine hormone definition, on the other hand, does not surprise you, this chemical, which is accepted as a hormone due to its duties in the body, appears in many areas, from attention deficit and focus problems to its effects on stress and excitement, its effect on being happy and mobility. Now that we know what is dopamine hormone, let's take a quick look at the picture that will arise in the absence of this chemical.
   As we mentioned, the decrease in the amount of this hormone in our body is encountered with problems such as depression and Parkinson's disease. However, tremors, loss of balance, weight gain, low energy, feeling of fatigue and weakness, despair and suicidal thoughts, hallucinations and anxiety may occur. All this can occur due to the deficiency of this chemical in our body. While this situation raises the question of what should we do to increase the dopamine level, it should be remembered that the level of this chemical is not in balance, that is, it is also a problem. What we call dopamine excess usually occurs due to excessive production of dopamine in the brain. It can cause conditions such as anxiety. We do not dwell on it, as it is not a very common condition, but we often find low dopamine levels. Even let's remember what low serotonin comes to mind. Low serotonin prevents pleasure and pleasure, just like dopamine, and prevents movement of the person. For this reason, we are talking about chemicals that need to be increased in the body or whose production should be supported.
   Let's talk about how to increase dopamine… Dopamine production in the body can be promoted in various ways. For example, the amino acid called Tyrosine increases the secretion of this hormone, and consuming protein sources rich in this amino acid can be an important solution at this point. Even the use of protein powder will be a practical choice. On the other hand, a probiotic-rich diet is recommended. For this, yoghurt and kefir consumption, which we can clearly feel that it is good for mental health, will be the right choice. We regularly know that exercising is a protector against many health problems. It should also be remembered that there is an important activity that will increase the level of this hormone in question. Sleeping order is a very important factor… Insufficient sleep can disrupt the secretion system and this may create dopamine deficiency.
   One of the practical ways to eliminate this deficiency is to take dopamine supplements. The products sold in the form of dopamine ampoules allow us to take this chemical into our body in a much more practical way and eliminate many problems we experience due to deficiency. Of course, it is very important to change our diet and living conditions, but getting quick results with such supplements will also be a logical choice. If you are experiencing such problems due to the drop of this hormone, you should know that you need to keep the level of this chemical in balance.

The Formation of Norepinephrine

The body creates norepinephrine as follows:

Phenylalanine-> Tyrosine-> L-dopa-> Dopamine -> Epinephrine-> Norepinephrine.

In general, the effect of norepinephrine on the target organ changes the body in a way that leads more to active body movement, often generating increased energy use and increased wear and tear (R) costs.

PHENYLALANINE
   It is an essential amino acid that must be taken through the diet because the body cannot synthesize by itself but is needed for the production of tyrosine secreted from the thyroid gland.
   Except for phenylketonuria patients, which is seen one in 4000, it is essential that all people have a daily diet.
   Important Note: Phenylalanine nourishes cancer cells, just like sugar.
   Most protein-rich foods contain good amounts of L-phenylalanine. These include the following foods:
• Eggs
• Milk and milk products
Legumes (beans and peanuts)
• Sunflower and sesame seeds
• Red meat and poultry
• The fish
Eating a variety of good protein sources will provide you with optimal phenylalanine intake

TYROSINE
   Tyrosine is often used as a precursor to the class of neurotransmitters called catecholamines (dopamine, norepinephrine and epinephrine) in the brain.
   High tyrosine levels increase the production of these neurotransmitters if our body needs more than these.

   As a result of tyrosine consumption, the increase of catecholamine levels enables antioxidant properties to be protected and protect brain cells from oxidative damage (neuroprotective activity). Tyrosine can also help prevent dementia, parkinson or other diseases related to the nervous system.
   . It reduces stress
   . Makes one feel good
   . Increases attention and concentration
   . Improves cognitive functions
   . Has effects to protect memory

L-DOPA

   Levodopa is the precursor of dopamine, since dopamine does not cross the blood brain barrier, levodopa is given instead.

If you suffer from insomnia as well as depression, norepinephrinergic therapy is likely to worsen your condition.